Novel 11{62 -alkoxy steroids

ABSTRACT

11 Beta -ALKOXY- Delta 4-GONENES OF THE FORMULA WHEREIN R and X are alkyl of 1 to 4 carbon atoms, R1 is a saturated or unsaturated hydrocarbon of 1 to 6 carbon atoms, R2 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and Y and Y&#39;&#39; are selected from the group consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of 1 to 18 carbon atoms which possess anti-androgenic and anti-estrogenic activity, their preparation and novel intermediates.

United States Patent Bucourt et al.

[ 1 Sept. 16, 1975 NOVEL l IB-ALKOXY STEROIDS Inventors: Robert Bucourt, Paris; Andre Pierdet, Noisy Le Sec; Jean Salmon,

Paris, all of France Assignee: Roussel-UCLAF, Paris, France Filed: Mar. 4, 1974 I Appl. No.2 447,561

Related US. Application Data Division of Ser. No. 201,564, Nov. 23, 1971, Pat. No 3,810,887.

US. CL... 424/243; 260/397.45; 260/239.55 C;

260/3975 Int. Cl. A61K 31/56 Field of Search 424/243; 260/397.45

References Cited UNITED STATES PATENTS 9/1970 Bertin et al. 260/397.45 5/1971 Primary Examiner-Elbert L. Roberts Attorney, Agent, or Firm-Hammond & Littell Bcrtin et al. 26O/397.45

[57] ABSTRACT I l Balkoxy-A-gonenes of the formula 8 Claims, No Drawings NOVEL l lB-ALKOXY STEROIDS PRIOR APPLICATION This application is a division of our copending, commonly assigned application Ser. No. 201,564, filed Nov. 23, 1971, now US. Pat. No. 3,810,887.

STATE OF THE ART llfi-alkoxy-gonanes having 2 or 3 double bonds in the nucleus are known. For example French Pat. No. 1,519,520 discloses l l-alkoxy-A -gonadiene-3-ones having a hypophysial inhibiting activity and a hypocholesterolemia activity superior to that of the corresponding 1 l-hydroxy-derivatives because of their important estrogenic activity.

French BSM Pat. No. 5,519M discloses that l 1- methxy-A- l0)-estratrienes oxygenated in the 3- and 17-positions have a considerable estrogenic activity while the corresponding 1 l-hydroxy compounds have a very weak estrogenic activity. The teaching of the prior art would therefore lead to the conclusion that introduction of an alkoxy group in the 1 l-pos ition leads to increased estrogenic activity. Also, 1 l-hydroxy derivatives of l7a-methyl and l7a ethyl-l9-nortestosterone are known to have anabolic and androgenic activity [Magerlein et al., J.A.C.S., Vol. 80 (1958) p.

OBJECTS OF THE INVENTION It is an object of the invention to provide the novel compounds of formula I and their enolic esters.

It is another object of the invention to provide a novel process for the preparation of the compounds of formula I.

It is a further object of the invention to provide novel intermediates for the preparation of the compounds of formula I.

It is a further object of the invention to provide novel anti-hormonal compositions.

It is an additional object of the invention to provide a novel method of blocking hormonal activites in warm'blooded animals.

These and other objects and advantages of the invention will become obvious from the following detailed description.

THE INVENTION The novel llB-alkoxy-A -g0nenes of the invention have the formula wherein R and X are alkyl of l to 4 carbon atoms, R is a saturated or unsaturated hydrocarbon of l-to 6 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and Y and Y are selected from the group consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of l to 18 carbon atoms.

Preferably, the substituent R is an alkyl such as methyl, ethyl, n-propyl, isopropyl or n-butyl. X is pref- 5 erably an alkyl such as methyl, ethyl, n-propyl, isopropyl or n-butyl. R is preferably alkyl of l to 4 carbon atoms such as methyl, ethyl, or propyl; cycloalkyl of 3 to 6 carbon atoms such as cyclopropyl, cyclopentyl or cyclohexyl; alkenyl of 2 to 4 carbon atoms such as vinyl, allyl, 2-methylally or 2-butenyl; alkynyl or haloalkynyl of 2 to 4 carbon atoms such as ethynyl, lpropynyl, 2-propynyl, 2-butynyl, butadiynyl, chloroethynyl or trifluoropropynyl; and phenyl.

When R represents the acyl residue of an organic carboxylic acid it is preferably the residue of a saturated or unsaturated aliphatic or cycloaliphatic acid and more particularly the residue of an alkanoic acid such as acetic, propionic, butyric, isobutyric or undecylic acid; the residue of a cycloalkylcarboxylic or (cycloalkyl) alkanoic acid'such as cyclopropyl, cyclopentyl or cyclohexylcarboxylic acid, cyclopentyl or cyclohexyl,

acetic or propionic acid; the residue of benzoic acid or a phenyl-alkanoic acid such as phenylacetic or phenylpropionic acid; the residue of an aminoacid such as die thylaminoacetic or aspartic acid; or the residue of formic acid.

Examples of specific preferred compounds are 1 1B- methoxy- 1 7a-ethynyl-A-estrenel 7,8-01-3-one, l 1,8- ethoxy- 1 7a -ethynyl-A -estren'el 7B-ol-3-one, l 1 B- methoxyl 3B-ethyll7oi-ethynyl-A -gonene-1 75-01- 3-one, 1 l B-methoxy-17a-ethynyl-l 7B-butyryloxy-A estrene-3-one, l l B-methoxy- 1 3B-ethyl-l 7a-vinyl-A"- gonene-l7/3-ol-3-one and 3,17/3-dibutyryloxy-l 1B- methoxyl 7a-ethynyl-A -estradiene.

The novel process of the invention for the preparation of the l IB-alkoxy-steroids comprises reducing by the Birch reaction a l lB-alkoxy-A" -gonatriene of the formula II To 2 \Y' 0 wherein x, R, Y and Y have the above definitions and Y" is alkyl of l to 4 carbon atoms to form a 13 gonadiene of the formula reacting the latter with a ketalization agent to form a which is then reacted with a ketalization agent. This A -gonene of the formula method results in a mixture of 3-ketal-A and 3- ketal-A derivatives which may be used for the next step or from which the predominant 3-ketal-A X R 5 isomer can be isolated.

K OH The compounds of formula I can also be prepared by W subjecting a A -gonatriene of formula II to the Birch reduction to obtain the corresponding A gonadiene of formula III, reacting the latter with an oxidizing agent to obtain a A -gonadiene-l7-one of the f I ormula Y wherein K is a ketaI group, reacting the latter with an oxidization agent to form a A -gonene-l 7-one of the VII formula II Y O Y X0 f V reacting the latter with an organometallic reagent wherein the organo is R as defined above to form the K corresponding A -gonadiene-178-01 of the formula I &' l

VIII reacting the latter with an organometallic reactant wherein the organo is R as defined above to form a l7a-R,-A -gonenel7B-ol of the formula X0 OH and subjecting the latter to acid hydrolysis to form the 40 corresponding compound of formula I wherein R is hy- 1 I drogen. The latter may be esterified as before.

VI To prepare compounds of formula I wherein R is a saturated hydrocarbon of 1 to 6 carbon atoms, the Y starting llfi-alkoxy-A "-gonatriene may be substituted in the 17a-position with R before the Birch reduction as it is not concerned by this step and the resulting A -gonadiene of the formula and subjecting the latter to acid hydrolysis to obtain the corresponding compound of formula I wherein R is hydrogen. The latter compound may be acylated with an X r OH organic carboxylic acid of 1 to 18 carbon atoms or a functional derivative thereof. R IX In a modification of the process, the ketalization of the A -gonadiene of formula III may be effected in two steps by acid hydrolysis of the compound of formula III to form a A-gonene of the formula {Y wherein R is a saturated hydrocarbon is subjected to 1 acid hydrolysis to form the corresponding 1 l B-alkoxyl3B-R-A -gonene-l7,8-01-3-one which may be csterified if desired.

The Birch reduction may also be used by the method of Ruggieri [Anali di Chimica, Vol 48 (1958), p. 1042] with an 1 l B-alkoxyl 7a-ethynyl-A "-gonatriene by subjecting the latter to the action of an alkali metal III amide (sodium, potassium or lithium in liquid ammonia) to form the derivative where M is the alkali metal which avoids hydrogenolysis of the l7-hydroxyl. This permits the prep aration of a l lB-alkoxyl 3,8-alkyll 7a-vinyl-A -gonene of the formula X0 R H when by reacting a compound of the formula with an alkali metal amide to form a compound of the formula where M is an alkali metal and subjecting the latter to the Birch reduction followed by acid hydrolysis.

The Birch reduction is preferably effected with the aid of an alkali metal such as lithium, potassium or sodium in liquid ammonia in the presence of an alcohol. The reaction may be effected in the presence of an additional solvent such as tetrahydrofuran, dioxane or ethyl ether. The alcohol is preferably an .alkanol of l to 6 carbon atoms such as methanol, ethanol, isopropanol or tert-butanol.

The ketalization agent is preferably an alkanol of l to 4 carbon atoms, or an alkylene glycol with 2 to 4 carbon atoms such as ethylene glycol or propylene glycol. The reaction is carried out in the presence of an acidic catalyst. The ketalization can also be effected by an exchange reaction with a dioxolane in the presence of an acidic catalyst. The dioxolane may be, for example, Z-methyl-Z-ethyl-dioxolane, 2-methyl-2-phenyldioxolane, 2-methyl-4-(4-methylbenzyl )-dioxolar. 2,2-dimethyl4-(4'-methylbenzyl)-dioxolane,

2-chloro-methyl-dioxolane, ZB-chloroethyl-dioxolane, or 2-methyl-2-isopropenyl-dioxolane. The acidic catalyst is preferably a mineral acid such as hydrochloric acid, perchloric acid or sulfuric acid, a sulfonic acid such as para-toluene sulfonic acid or also boron trifluoride.

The oxidation of the l7B-hydroxyl compounds to l7B-ketone compounds is carried out with an oxidation agent in a neutral or basic medium in order to avoid cleavage of the protective group of the 3-ketone (ketal or enol ether). The oxidation agent is preferably a metal derivative as oxidizing agent (particularly a metal oxide), or as a catalyst (Oppenauer Reaction). The oxidation reaction is preferably effected by the Oppenauer method, consisting in oxidizing with a ketone in the presence of an aluminum alcoholate. The ketone is preferably a lower aliphatic ketone such as acetone, methylethyl ketone, methylisobutyl ketone or a cycloalkanone such as cyclohexanone. The aluminum alcoholate is preferably an aluminum trialkanolate derived from a lower alkanol such as aluminum isopropylate or tert-butylate. The oxidation reaction may also be effected with a metal oxide, preferably chromic anhydride in pyridine.

The introduction of a hydrocarbon substituent into the l'ia-position is effected with the aid of an organometallic reagent where the organo is R as defined above. Preferably, either organomagnesium halides of the formula R,MgX where X is a halogen atom, and particularly a chlorine, bromine or iodine atom, or alkali metal derivatives of the formula R M, where M is an alkali metal atom and particularly a lithium, sodium or potassium atom are used. The organometallic reagents are generally prepared just before use.

The hydrolysis of the ketals or the enol ethers leading to the regeneration of the ketone in the 3-position is effected with an acid able to effect at the same time as the hydrolysis, isomerization of the double bond A to A. Preferably a mineral acid is used such as hydrochloric acid, sulfuric acid or perchloric acid in an aqueous medium or a carboxylic acid such as acetic acid, formic acid, citric acid or trichloracetic acid in an aqueous medium or a mixture of these acids.

The functional derivatives of the organic carboxylic acids of the formula R OH wherein R is an acyl radical defined as above are the anhydrides or the acid chlorides.

The novel antiandrogenic and antiestrogenic compositions of the invention are comprised of an antihormonal effective amount of a compound of formula I or its enol ester and a pharmaceutical carrier. The compositions may be in the form of injectable solutions or suspensions in ampules or multi-dose flacons or in the form of implants, tablets, coated tablets, sublingual tablets, capsules, suppositories, ointments, creams or lotions made in the usual manner.

The compositions have the advantage that the etherification in the l l-position of the active ingredient causes the disappearance of androgenic and anabolic activities characteristic of l9-nor-testosterone compounds and the disappearance of estrogenic activities characteristics of gonadienic and A -gonatrienic compounds and causes the appearance of anti hormonal properties. The said compounds have a total lack of peripheral hormonal properties which cause disturbing side effects in therapeutics such as vascular troubles, weight gains, bleeding, chloasma and loss of hair.

The compositions are useful as medicants for the treatment of prostatic adenoma, hyperandrogenia, acne, hirsutism and also treatment of troubles caused by hyperestogenism. They are also useful for resting ovaries by blocking ovulation for example in the treatment of sterility, dysmenorrheas or ovarian dystrophies.

The compositions may also contain other active pharmaceutical compounds such as estrogens like ethynyl estradiol, mestranol or llflmethoxy-l7cx-ethynylestradiol. These compositions associated with estrogens are useful estroprogestative formulations for contraceptive activity.

The novel method of the invention for inducing antihormonal activity in warm-blooded animals comprises administering to warm-blooded animals an effective amount of at least one compound of formula I or its enol esters. The said compounds may be administered orally, perlingually, transcutaneously, rectally or topi cally. The usual useful dose is 0.008 to 0.83 mg/kg depending on the method of administration and the specific compound.

ln the following examples there are described several preferred embodiments to illustrate the invention. However, it should be understood that the invention is not intended to be limited to the specific embodiments.

EXAMPLE 1 Preparation of 1 1 B-Methoxyl 7a-Ethynyl-A -Estrene- 1 7B-o1-3-One Step A: 3,1 1B-dimethoxy-A -estradiene-17,8-01

gm of 3,11,B-dimethoxy-A" -estratriene-17B- ol, 72 ml of tetrahydrofuran and 3.6 ml of ethanol were cooled to 40C, and 92 ml of liquid ammonia were added thereto with agitation. Then, 1.6 gm of lithium was added and the reaction mixture was agitated for two hours between 3 5C and 40C under an inert atmosphere. The mixture was again brought to 40C, and after 26 ml of ethanol were added, ammonia was evaporated by heating. 110 ml of water were added without surpassing +C and the mixture was poured into iced water, agitated for one hour at +5C, and vac uum filtered. The precipitate was washed with water and dried in vacuo to obtain 10 gm of 3,1 1,8- dimethoxy-A -estradiene-17B-o1 as colorless crystals melting at 189C and soluble in ethanol and benzene, and insoluble in water.

As far as is known, this compound has not been described in the literature.

Step B: 1 lfi-methoxy-A estrene-l7,B-ol-3-one 10 gm of 3,11,B-dimethoxy-A -estradiene17/3-01 were refluxed for one hour with agitation and under nitrogen with 100 ml of methanol and 10 ml of N hydrochloric acid and after the solution was brought to room temperature, the mixture was poured into iced water. The mixture was extracted with methylene chloride, and the methylene chloride phase was washed with water, dried over sodium sulfate, filtered and evaporated to dryness in vacuo. The residue was left overnight at 0C in the presence of some ether and dried to obtain 9.9 gm of 11B-methoxy-A-estrene-l7,8-01-3-one. The product was purified by crystallization from isopropyl ether to obtain 6.42 gm of the desired product in the form of colorless needles soluble in ethanol and benzene, and insoluble in water. The product melted first at 1 14C, then 120C and had a specific rotation [01],, +82(c=0.6% in dioxane).

Analysis: C, H O molecular weight 304.41.

Calculated: %C 74.96; %H 9.27.

Found: %C 74.8; %H 9.0.

U.V. Spectrum (ethanol):

Max. at 242-243 ma: E 536 e 16,300

As far as is known, this compound has not been described in the literature.

Step C: 3,3-ethylenedioxy-l 1 B-methoxy-A estrene-17B-ol 15 gm of 1 l ,8-methoxy-A -estrenel7B-ol-3-one were dissolved at reflux with agitation in 400 m1 of benzene containing mg of para-toluene sulfonic acid and 80 ml of ethylene glycol and the reflux was maintained for 7 hours. The mixture was brought to room temperature and ml of a saturated aqueous solution of sodium bicarbonate were added. The organic phase was decanted, and the aqueous phase was extracted with benzene. The combined benzene phases were washed with water until the wash water was neutral and after a drop of triethylamine was added, the solution was dried over sodium sulfate and evaporated to dryness in vacuo. The residue was dissolved in 50 ml of benzene, and then precipitated by the addition of isopropyl ether containing 1% of triethylamine. The precipitate was recovered by vacuum filtration, was washed with isopropyl ether containing 1% of triethylamine and dried in vacuo to obtain 13.10 gm of 3,3-ethylenedioxy-l lB-methoxy- A -estrene-l 78-01 as a colorless solid product soluble in acetone and ethyl acetate, slightly soluble in benzene and ether, and insoluble in water. The product melted at 104-106C.

As far as is known, this compound has not been described in the literature.

Evaporation of the mother liquor, gave a second crop of 4.5 gm of compound constituted of a mixture of the preceding compound and the corresponding A isomer or 17.6 gm total product which was utilized as is in the following step.

As far as is known, the A isomer has not been described in the literature.

Step D: 3,3ethylenedioxy-1 lfi-methoxy-A estrene-17-one 17.7 gm of the product obtained in Step C were dissolved in 500 ml of toluene and 200 m1 of cyclohexanone at reflux under an inert atmosphere and after 100 m1 of the solvent were distilled off, 400 ml of a toluene solution of 2.28 gm of aluminum isopropylate per 100 ml were added over 15 minutes while maintaining a constant level of the solvent by distillation and the reflux. A solution of 100 gm of potassium sodium tartrate in 1000 ml of water were added while still maintaining the constant level of the solvent and the solution was cooled to room temperature, and then extracted with benzene. The benzene phases were washed with water until the wash water was neutral and then one drop of triethylamine was added. The solution was dried over sodium sulfate and then was evaporated to dryness in vacuo. The residue was chromatographed on silica and eluted with a 8:2 benzene-ethyl acetate mixture with 1% of triethylamine to obtain 3.56 gm of 3,3- ethylenedioxy- 1 l B-methoxy-A -estrene 1 7-one melting at first 1 18C, then l35l40C. The product occurred as a colorless solid product soluble in alcohol, acetone, benzene and chloroform, slightly soluble in ether and insoluble in water.

The compound was accompanied by 6.44 gm of 3,3- ethylenedioxy-l l fi-methoxy-A -estrenel 7-one melting at 128C.

The mixture of the two compounds was used as is in the following step.

As far as is known, these compounds have not been described in the literature.

Step E: 3 ,3-ethylenedioxy- 1 l B-methoxy-l 7ozethyr1yl-A -estrene-l 7B-ol Into 250 ml of a toluene solution of 2.76 gm of sodium tert-amylate per 100 ml, a stream of acetylene was passed for two hours with agitation and then 40 ml of toluene were added thereto. 10 gm of the mixture of 3 ,3-ethylenedioxy-l 1 B-methoxy-A -estrenel 7-one and 3,3-ethylenedioxy- 1 l fl-methoxy-A -estrenel7-one of Step D and 25 ml of tetrahydrofuran were added to the mixture and the passage of the acetylene stream was maintained for five hours. The reaction mixture was swept with an inert atmosphere and cooled to +10C. A solution of 25 gm of ammonium chloride in 150 ml of water was added, and the mixture was agitated for minutes. The organic phase was decanted, and the aqueous phase was extracted with toluenedThe combined toluene phases were washed with water until the wash water was neutral, dried over sodium sulfate and evaporated to dryness in vacuo to obtain 9.47 gm of a mixture of 3,3-ethylenedioxy-l lB-methoxy-l7aethynyl-A -estrene-l7B-ol and 3,3-ethylenedioxy- 1 IB-methoxyl7a-ethynyl-A -estrene-17,8-01.

The mixture of the two compounds obtained in Step E with a solution of 180 ml of acetic acid, 6 ml of hydrochloric acid and 14 ml of water was stirred under a nitrogen atmosphere for 1 /2 hours and the reaction mixture was poured into a water-ice mixture. The reaction mixture was agitated for 2 hours and then was vacuum filtered. The precipitate was washed with water and dried in vacuo to obtain 5.91 gm of crude 11B- methoxy-l 7ozethynyl-A-estrenel 7/3-ol-3-one. By making the mother liquor alkaline, a second crop of 1.3 gm of product were obtained for a total of 7.21 gm. The 7.21 gm of product were chromatographed over silica, and eluted with a 5-5 benzene-ethyl acetate mixture. 6.6 gm of product were impasted with refluxing benzene and then was allowed to crystallize for 2 hours at 15C. The mixture was vacuum filtered, and the recovered precipitate was washed with benzene and dried in vacuo to obtain 5.2 gm of 11,8-methoxy-l7a-ethynyl- A -estrene-l7B-ol3-one melting at 2l22l 3C. The product occurred as a colorless solid product soluble in alcohol, acetone, benzene and chloroform, slightly soluble in other and insoluble in water.

For analysis, the compound was crystallized from ethyl acetate and the melting point remained the same.

Analysis: C21H28Og; molecular weight 328.44. Calculated: %C 76.79; %H 8.59. Found: %C 77.0; %H 8.6.

U.V. Spectrum(ethanol):

Max. at 242243 m E 508 e 16 700 As far as is known, this compound has not been described in the literature.

The starting 3,1 lB-dimethoxy-A -estratriene- 173-01 and the other l la1koxy-l3B-alkyl-A gonatrienes were obtained by the processes described in Belgian Pat. No. 699,393 or Belgian Pat. No. 699,394.

EXAMPLE ll 1 lB-methoxy- 1 7a-ethynyll 7B-butyryloxy-A -estrene- 3-one A mixture of 20 ml of benzene, mg of paratoluene sulfonic acid and 1.8 ml of butyric anhydride was heated and 2 ml of benzene were distilled off. The mixture was brought back to room temperature, and 1 gm of l lB-methoxy-l 7a-ethynyl-A -estrenel 7B-ol- 3-one was added. The reaction mixture was agitated for 17 hours under nitrogen, and cooled to between 0C and +5C. 1.8 ml of triethylamine were added, then 1.8 ml of methanol, followed by agitation for 15 minutes. The mixture was poured into water and was extracted with ether. The ether phases were washed with water, then several times with an aqueous solution of sodium bicarbonate until the pH of the wash water was neutral. The solution was dried over sodium sulfate and evaporated to dryness in vacuo. The residue was purified by chromatography over silica and elution with a 7:3 benzene-ethyl acetate mixture to obtain 710 mg of 11,8- methoxy-l 7ot-ethynyll 7 ,Bbutyryloxy-A est'rene- 3-one in the form of a colorless solid product soluble in alcohols, ether, chloroform and benzene, and insoluble in water.

U.V. Spectrum (ethanol):

Max. at 241 my; E 402 e 16 000 IR. Spectrum(chloroform):

Presence of C E C, ester, C-OC and conjugated ketone.

As far as is known, this compound has not been described in the literature.

The chromatography also isolated a second product whose U.V. and IR. spectral analysis showed that it was the 3-enolic ester of the said product or 3,17,8- dibutyryloxy-l lB-methoxy-l 70z-ethynyl-A estradiene.

As far as is known, this compound has not been described in the literature.

EXAMPLE Ill Preparation of l l ,B-Ethoxyl 7a-Ethynyl-A -Estrene 1 7,8-ol-3-one Step A: 3-methoxy-l lB-ethoxy-A -estradiene- 178-01 320 ml of ammonia were cooled to -70C and 8 gm of 3-methoxy-l lfi-ethoxy-A -estratriene-l 7B-ol (obtained by the process of the French Pat. No. 1,514,122), 160 ml of tetrahydrofuran and ml of tert-butyl alcohol were added at 33C with stirring. Finally, 13.5 gm of sodium were added, and the mixture was agitated for 1% hours at -33C and again 1.5 gm of sodium were added. The ammonia was removed with a stream of nitrogen, and the residue was cooled to -30C. 500 ml of water were added and the mixture was vacuum filtered. The recovered precipitate was washed with water to obtain 6.8 gm of 3-methoxy-l 1B- ethoxy-A -estradiene- 1 78-01 which was used as is in the next step. The compound was a colorless solid product melting at C.

As far as is known, this compound has not been described in the literature.

Step 13: 3,3-ethylenedioxy-l lB-ethoxy-A -estrene- 1713-01 The 6.8 gm of 3-methoxy-l lB-ethoxy-A estradiene-l7B-ol obtained in Step A were dissolved in 108 ml of methylethyldioxolane with 2% of glycol, and 136 mg of para-toluene sulfonic acid were added thereto. The solution was allowed to stand for 60 hours at room temperature, and then was poured into water. The mixture was extracted with methylene chloride, and the organic phases were dried over sodium sulfate and distilled to dryness in vacuo. The residue was chromatographed over silica and eluted with a 6:4 benzeneethyl acetate mixture containing 1% of triethylamine. The residue was dissolved in ml of ether, and the solution was filtered, and concentrated to half its volume. 3 ml of isopropyl ether were added, and the solution was concentrated to the start of crystallization, icecooled for 1 hour, and vacuum filtered. The recovered precipitate was washed with ice-cold isopropyl ether and dried to obtain 2.65 gm of 3,3-ethylenedioxy-l 1B- ethoxy-A -estrene-17,8-01 in the form of a colorless solid product soluble in chloroform and benzene, and insoluble in water, and melting at 128C.

LR. Spectrum(chloroform):

Absence of carbonyl, presence of OH and ketal.

As far as is known, this compound has not been described in the literature.

Step C: 3,3-ethylenedioxy-l lB-ethoxy-A -estrenel7-one A mixture of 2.6 gm of 3,3-ethylenedioxy-l 1/3- ethoxy-A -estrene-173-01, 73 ml of toluene and 30 ml of cyclohexanone was heated, and ml of solvent was distilled off. 58 ml of a solution of 2.28 gm of aluminum isopropylate in 100 ml of toluene were added thereto while distilling to maintain a constant volume. 100 ml of toluene were added while maintainin a constant volume, and the solution was refluxed, with agitation, for 1 /2 hours. The mixture was cooled to C and the solution was vacuum filtered. The filter was washed with methylene chloride and the organic phase was concentrated in vacuo. The obtained oil was subjected to a steam distillation for 4 hours, and the oily residue was extracted with benzene. The benzene phase was washed with water, dried over sodium sulfate and distilled to dryness in vacuo. The residue was dissolved in 4 ml of methylene chloride, and after the solution was concentrated to half its volume, 4 ml of isopropyl ether were added. The solution was concentrated to the start of crystallization, ice-cooled for 1 hour, and vacuum filtered. The recovered precipitate was dried to obtain 1.365 gm of 3,3-ethylenedioxy-l lfi-ethoxy-A estrene-l7one melting at 130C. The product occurred as a colorless solid product soluble in chloroform, benzene and alcohols, and insoluble in water.

Further crystallization from the mother liquor gave 1.36 gm of product melting at 125C which was purified by chromatography on silica and elution with a 9:1 benzene-ethyl acetate mixture containing 1% of triethylamine.

Analysis: C2 H O molecular weight 360.48. Calculated: %C 73.29;%H 8.94. Found:%C73.3;%H9.2.

LR. Spectrum(chloroform):

Absence of OH, presence of cyclopentanone and ketal.

As far as is known, this compound has not been described in the literature.

Step D: 3,3-ethylenedioxy-l l,B-ethoxy-l7aethynyl- A -estrenel 75-01 A mixture of 83 ml of tetrahydrofuran, 38 ml of hexamethyl phosphoro triamide and 4.72 gm of potassium tert-butylate was cooled to 0C and a stream of acetylene was passed therethrough for 1 /2 hours. 'A solution of 3.37 gm of 3,3-ethylenedi0xy-11,8-eth0xy-A estrene-l7-one in 5 ml of tetrahydrofuran was added and the mixture was agitated for 1% hours at 0C while continuing the bubbling of acetylene. Excess acetylene was removed by a stream of nitrogen and the suspension was poured into 500 ml of an aqueous saturated solution of ammonium chloride. The mixture was extracted with ether, and the ether phases were washed with water, dried over sodium sulfate and distilled to dryness in vacuo to obtain 3.74 gm of 3,3- ethylenedioxy-l 1,8-ethoxy-17a-ethynyl-A -estrene- 1713-01 which were used as in the following step.

LR. Spectrum(chloroform):

Absence of C=O, presence of OH, C CH and ketal.

As far as is known, this compound has not been described in the literature.

Step E: 1 IB-ethoxy- 1 7cxethynyl-A"-estrene- 1 713-01- 3-one 3.7 gm of 3,3-ethylenedioxy-l1,8-ethoxy-17aethynyl-A -estrene-l73-01 dissolved in 61.2 ml of acetic acid, 2.04 ml of hydrochloric acid and 4.76 ml of water were agitated for 1V2 hours at room temperature and the solution was poured into a water-ice mixture. The mixture was agitated for 2 hours, and the precipitate was recovered by vacuum filtration, was washed with water and dried to obtain 2 gm of crude product melting at C. By making the mother liquor alkaline, a second crop of 100 mg of product melting at 166C was obtained.

The two combined crops were dissolved in 4 ml of methylene chloride, and the solution was chromatographed on magnesium silicate and eluted with methylene chloride. The obtained solution was concentrated in vacuo to 2 ml and 10 ml of isopropyl ether were added thereto. The mixture was concentrated by heating in vacuo, ice-cooled for one hour, and vacuum filtered. The recovered precipitate was washed with iced isopropyl ether and dried to obtain 1.6 gm of pale yellow crystals melting at 173C. The crystals were dissolved in 3 ml of hot methanol containing 20% of water. The solution was ice-cooled for 1 hour and vacuum filtered to obtain two crops for a total of 1.1 16 gm of 1 1,8-ethoxy-1 7a-ethynyl-A -estrene- 1 7B-ol-3-one melting at 174C. The product occurred as colorless solid product soluble in chloroform, benzene and alcohols, and insoluble in water. By continuing ice-cooling of the methanol solution, a third crop of 231 mg of product melting at C, was obtained. The mother liquors were passed over silica together with the third crop, and eluted with a 5:5 benzene-ethyl acetate mixture. The precipitate was crystallized from iced isopropyl ether to obtain 271 mg of the product melting at 174C.

Analysis: C l-l Q molecular weight 342.46.

Calculated: %C 77.1; %H 8.8.

Found: %c 76.8; %H 8.9.

LR. Spectrum( chloroform Presence of OH at 3595"", of -C CH at 3300", of conjugated ketone at 1662" and of U.V. Spectrum(ethanol):

Max. at 253 mu: E 484 e 16,600

As far as is known, this compound has not been described in the literature.

EXAMPLE 1v Preparation of l 1 ,8-Methoxy- 1 3B-Ethy1-l 7a-Vinyl-N-Gonene- 1 7,8- o1-3-One Step A: 1 IB-methoxy-l 3B-ethy1-A -gonadiene- 3,17-dione 8.967 gm of 13B-ethyl-A -gonadiene-1 1,8-01-3, l 7- dione (obtained by the process of French Pat. No. 1,514,088) were dissolved in 448 ml of methylene chloride containing 1% methanol, and 0.88 ml of 70% perchloric acid was added thereto. The mixture was agitated for minutes and then was poured into a mixture of equal parts of water and a saturated aqueous so lution of sodium bicarbonate and extracted with methylene chloride. The organic phases were washed with an aqueous saturated solution of sodium bicarbonate, then with water, and dried over sodium sulfate, vacuum filtered and distilled to dryness in vacuo to obtain 9.628 gm of 1 lfi-methoxy- 1 3 B-ethyl-A- -gonadiene-3 ,17- dione which was used as is in the next step.

For analysis the compound was crystallized from isopropyl ether and it occurred as colorless crystals soluble in benzene, ethanol and chloroform and insoluble in water, and melting at 1 C and having a specific rotation [01],, -21.5. i 2.5(c 0.3% in ethanol).

Analysis: C H O molecular weight 314.41.

Calculated: %C 76.40, %H 8.34.

Found: %C 76.4; %H 8.2.

U.V. Spectrum(ethanol):

Max. at 236 mu: E 147.

Max. at 292 mu; E 639; e 20,100

As far as is known, this compound has not been described in the literature.

Step B: 1IB-methoxy-13B-ethyl-A" -gonatriene- 3-ol-l 7-one A solution of 9.088 gm of llB-methoxy13B-ethy1- A -gonadiene3,17-dione dissolved in 475 ml of methanol and 5.63 gm of 13.6% palladium hydroxide on magnesia was refluxed for 2% hours with agitation under nitrogen and the solution was vacuum filtered. The filter was washed with boiling acetone and the filtrate was distilled to dryness in vacuo. The residue was taken up in volumes of refluxing methanol and the solution was concentrated to 10 volumes, cooled, icecooled for 3 hours, and vacuum filtered. The recovered precipitate was washed with iced methanol and dried to obtain 5.319 gm of l lB-methoxy-l3B-ethy1-A gonatriene-3-ol-17-one melting at 226C. For analysis, the compound was purified by a second crystallization and the melting point remianed unchanged.

The compound occurred as colorless crystals soluble in benzene, chloroform and ethanol, slightly soluble in methanol and insoluble in water. The product melted at 226C and its specific rotation was [ct] 129: 3(c 0.45% in ethanol).

Analysis: C H O molecular weight 314.41.

Calculated: %C 76.40; %H 8.34.

Found: %C 76.2; %1-1 8.3.

U.V. Spectrum(ethanol):

lnfl. towards 220 mu: E 234 lnfl. towards 228 mu: E 177 Max. at 281 mu: E 65; e 2050 lnfl. towards 286 mu: E 59; e 1860 LR. Spectrum(chloroform):

Presence of aromatic at 161 1 and 1587""", of OH at 3588""', of cyclopentanone and of CO--C.

As far as is known, this compound has not been described in the literature.

10.65 gm of were tert-butylate was dissolved in 213 ml of tetrahydrofuran with agitation and under an inert atmosphere and a stream of acetylene was passed into the solution for 15 to 20 minutes. 27 ml of hexamethylphosphorotriamide were then added and bubbling of acetylene was continued for 15 minutes. 5.093 gm of 1 1 B-methoxy- 1 3B-ethyl-A -gonatriene-3-01- 17-one were added, and the mixture was agitated under nitrogen while passing acetylene therethrough for 1 hour and 20 minutes. The mixture was cooled to between +5C and +10C and a solution of 6.35 ml of acetic acid and 77.5 ml of water was added. The mixture was agitated for 5 minutes, and the tetrahydrofuran was evaporated in vacuo. 8 ml of water were added, and the mixture was vacuum'filtered. The precipitate was washedwith water and dried in vacuo. The residue was dissolved in volumes of refluxing ethanol and the solution was concentrated andthen iced, and vacuum filtered. The recovered precipitate was washed with iced ethanol and dried in vacuo to obtain 3.8 gm of 1 l,8methoxy-13B-ethyl-17a-ethynyl- A- -gonatriene-3,l7B-diol melting at 305C.

For analysis, the product was crystallized from methanol and the melting point remained the same. The compound occurred as colorless crystals slightly soluble in alcohols, and insoluble in water, and melted at 305C. Its specific rotation was [(11 +8 i 2(c 0.6% in pyridine).

Analysis: C H O molecular weight 340.44.

Calculated: %C 77.61; %H 8.29.

Found: %C 77.6 %H 8.5.

1.R. Spectrum (Nujol):

Presence of OH, C =CH at 3535 and 3306"" and of aromatic.

U.V. Spectrum lnfl. towards 217-218mu: E 211 Infl. towards 222 mu: E 203 lnfl. towards 229 mu: E

Max. at 281 mp; E 57; e 1950 Max. at 287 mu: E 52; e 1780 As far as is known, this compound has not been de scribed in the literature.

The 1 1 ,B-methoxy-l 3B-ethyl- 1 7a-ethynyl-A gonatriene-3,17,B-diol was reacted with dimethyl sulfate to obtain 3,1 IB-dimethoxy-l3B-ethyl-17oz-ethyny1- A -gonatriene-17B-o1 which was treated with lithium in liquid ammonia to form the corresponding 17,21-dilithium derivative. The latter compound was then subjected to the Birch reduction with lithium and ethanol followed by acid hydrolysis to form 1 1B- methoxy- 1 3fl-ethyl-l7a-vinyl-A -gonene-17B-ol-3-one.

As far as is known, this compound has not been described in the literature.

EXAMPLE V Preparation of 1 lfi-Methoxy-13B-Ethyl-17a- Ethynyl-N-Gonene- 1 7B-ol-30ne 1 lB-methoxy- 1 3,8-ethy1-A -gonatriene-3-o1- 17-one of Step B of Example IV was reduced to form 1 lfi-methoxy-l 3B-ethyl-A -estratriene-Za ,1 7B-dio1 which was methylated to obtain 3,1 lB-dimethoxy-13B- ethyl-A" -gonatriene-17/3-01. Using the procedure of Example 1, the said product was subjected to the Birch reduction to form 3,11B-dimethoxy-l3B-ethyl- A -gonadiene- 1 75-01 followed by acid hydrolysis to obtain 1 lfi-methoxy-13/3-ethy1-A -gonene-17B-ol- 3-one. The latter product was treated with ethylene glycol to obtain a mixture of 3,3-ethylenedioxy-l 1B- methoxy- 1 3 B-ethy1-A -gonenel 7 8-01 and 3 ,3- ethylenedioxy-l lB-methoxy-l 3 B-ethyl-A -gonene- 1713-01 which was then oxidized to form a mixture 3,3- ethylenedioxy-l IB-methoxy- 1 3B-ethy1-A -gonenel7-one and its A -isomer. The latter was then ethynylated to form a mixture of 3,3-ethylenedioxy- 1 1 B-methoxyl 3B-ethyll 7a-ethyny1-A "-gonenel7,B-o1-and its A isomer which was acid hydrolyzed to form 1 IB-methoxy- 1 3 fi-ethyl- 17a-ethynyl-A gonene- 1 7B-o1-3-one.

As far as is known, this compound has not been described in the literature.

PHYSIOLOGICAL STUDY A. Antigonadotrophic activity Antigonadotrophic activity was determined in pubes- B. Antiestrogenic activity Antiestrogenic activity was investigated in immature mice by a technique suggested by Rubin [Endo. 1951, Vol. 49, Pg. 429] and similar to that of Dorfman et al [Methods in Hormone Research, Dorfman, 1962, Vol. II, Pg. 118]. 19 to 21 days old mice received daily, in a subcutaneous injection or orally for 3 days, either estradiol alone, or the test product alone, or estradiol and the test product. In the last case, the two steroids were injected at different points. The mice were sacrificed on the 4th day and their uteri were removed and weighed. Estradiol in an olive oil solution with 5% benzyl alcohol added was injected at a total dose of 0.27 and each injection was given in a volume of 0.1 ml/mouse. 1 1 B-methoxy- 1 7a-ethynyl-A -estrene-l 7/3-ol-3-one was used in an olive oil solution containing 5% benzyl alcohol and was administered in total doses of 1.1-3.3

and 10 'y and the injections were also givenin a volume of 0.1 ml/mouse.

The results are summarized in Table III.

cent rats weighing about 200 gm and llfi-methoxy- TABLE l7a-ethynyl-A -estrene-17B-ol-3-one in an olive oil solution containing 5% benzyl alcohol was administered /geru e weight of the subcutaneously in a volume of 0.2 ml at the rate of 12 I 25 Lots Doses uterus in mg treatments in 14 days. On the 15th day, the rats were C l o 9 ontro s .4 sacrlficed by a carotold cut and the semmal ves1cles, Estradio] 027 7 76.2 the prostate, the testlcles and the suprarenals were re- Test Product 1.1 'y 9.6

u I moved and we1ghed. The obtained results are summa' Test 'P +estrad1ol 0.27 rlzed In Table Test Product 3.3 3 10.6

Test Product 3.3 7 30.2 (60 TABLE I estradiol 0.27 7

Test Product 10 y 13.4 T t P d t 10 27.7 647 Test- Seminal Pro- Sups fg i O 27 z Daily icles Vesicles state rarenal Lots Doses in mg in mg in mg in mg C ntr ls 0 .950 40 360 In a second test, the test product was administered at ufiqnethoxy doses of 037-1 .1 and 3.3 3 under the same test condil7a-ethynyl-A 0.2 mg 2,620 314 240 41.1 tions. The results are summarized 1n Table IV. -estrene-l 7B (587() 33% 40 TABLE IV -o1-3-6ne 1 mg 2,070 128 97 40.7

(827() -307r) -73%) Average weight at the 5 mg 1,400 124 87 28.1 Lots Doses uterus in mg (-83% (36%) Controls 0 -y 10.3 45 Estrudiol 0.27 'y 69.8 Test Product 0.37 y 9.2 T t P d z .3 r 1 1,8-ethoxy-17a-ethynyl-A -estrene-17,8-01-3-one s gg f 8 Z 61 3 12/) was tested under the same conditions in a sesame oil Test Product 1.1 'y 9.6

Test Product 1.1 y 39.7 ("4771) solutlon contam ng 5% of benzyl alcohol and the re +estmdio| 017 y sults are shown in Table 11. Test Product 3.3 'y 27 Test Product 3.3 -y 32.4 (-5471) TABLE 11 estradiol 0.27 'y Test Seminal Pro- L g y i (551C188 Stine suPrdrenfll The test product was administered orally at doses of I I m In in 1n m in m v 0 S 0565 n g g g g 3.3 l 0 and 30 under the same test cond1t1ons and the Controls 0 3,300 1,078.2 557.8 49.4 results are reported in Table V.

llfi-ethoxy 0.2 mg 2,900 414.5 250.9 56.2 TABLE V -17a-ethynyl (-62%) -55% A estrene- Average weight of the l7B-ol-3-one 2 mg 1,800 92.0 45.3 44.0 Lots Doses uterus in mg 91 /r -92% 4571 Controls 0 'y 9.4 Estradiol 0.27 -y 76.2 Test Product 3.3 7 10.1 Test Product 3.3 41.9 (457 The Tables show that the sald products have an an- 5 ndi 0427 Z I tigonadotrophic activity with a clear anti-LH predomi- Test Product 10 7 t t fr m a dail dose of 200 and that the Test Pmduct 7 Da 5 g 0 y I :Y y +estradiol 0.27 y do not cause a suprarenal aplas1a at th1s dose. Test Product 30 7 18.9

TABLE V-Continued Average weight of the Lots Doses uterus in mg Test Product 30 y 25.7 (-687z) 7/BESTRADIOL 0.27 'y In a second test, the test product was orally administered at doses of 0.37-1.l and 3.3 y and the results are shown in Table VI.

Table VI -Continued Average weight of the Lots Doses uterus in mg Controls -y 10.3

Estradiol 0.27 7 69.8

Test Product 0.37 y 7.5

Test Product 0.37 7 49.5 (-29%) estradiol 0.27 y

Test Product 1.1 7 10.3

Test Product 1.1 'y 50.8 (2771) estradiol 0.27 7

Test Product 3.3 7 10.5 Test Product 3.3 y 43.4 (-38%) estradiol 0.27 'y 1 lfi-ethoxy- 1 7a'ethynyl-A -estrenel 7B-ol-3-one was tested under the same conditions and was used in a sesame oil solution administered subcutaneously. The results of Table VII were obtained:

TABLE VII Average Weights of the Lots Doses uterus en mg Controls 0 7 8.7

Estradiol 0.27 7 70.4

Test Product 1.1 7 130 Test Product 1.1 7 30.5 (5671) estrudiol 0.27 7

Test Product 3.3 7 13.0

Test Product 3.3 7 26.1 ("-6370 estradiol 0.27 7

Test Product y 18.2

Test Product 10 -y 22.6 (787() estradiol 0.27 -y l l B-methoxyl 7a-ethynyl l 7B-butyryloxy-A estrene-3-one was tested under the same conditions, and was administered subcutaneously in a sesame oil solution in doses of 10, 90 and 810 'y. The results of These results show that the 3 products possess a clear antiestrogenic activity towards estradiol and particularly that l l B-methoxy-l 7a-ethynyl-A -estrene-17B-ol- 3-one and 1lB-ethoXy-l7a-ethynyl-A -estrene-l7B-ol- 3-one are active both subcutaneously and orally starting at a dose of 1.1 y.

C. Progestomimetic activity The progestomimetic activity was determined by the CLAUBERG Test in which immature rabbits were first sensitized by subcutaneous administration of estradiol benzoate for 5 days at a daily dose of 10 7. They were then treated daily for 5 days with the test compound. The animals were sacrificed on the 6th day and the uterus sections were examined for lacy profileration of the endometrium characteristic of progesteromimetic action in Mac Phail units. llB-methoXy-l7a-ethynyl- A -estrene-17B-ol-3-one in an olive oil solution containing 5% of benzyl alcohol was administered orally at doses of and 250 y. The results are summarized in Table IX.

TABLE IX Daily doses Mac Phail Units Test Product 125 -y 1.8 250 -y 2.0

TABLE X Daily doses Mac Phail Units Test Product 500 y 2.2 2.5 mg 2.8

The results show that the test product is endowed with a considerable progestomimetic activity at the dose of 500 'y. g

D. Exogenous antiandrogenic activity The exogenous antiandrogenic activity was determined against testosterone propionate in castrated male rats by the method of Lerner described by Dorfman in Methods in Hormone Research, Vol. II, page 320. Young male rats, about 4 weeks old, were castrated and the treatment started on the day after castration and lasted 7 days. On the 8th day, the animals were sacrificed and the following organs removed: prostate, seminal vesicles and levator ani. l lB-methoxy-l7aethynyl-N-estrene-l7B-ol-3-one and testosterone propionate in olive oil containing 5% benzyl alcohol were administered separately subcutaneously with the test product at the dose of l'mg and testosterone propionate at the dose of 50 (daily doses per rat). A control group received the solvent only, a group of rats received subcutaneously 50 'y of testosterone propionate, a group of rates received subcutaneously 1 mg of the test product and a group of rats received subcutaneously 1 mg of the test product and subcutaneously 50 y of testosterone propionate. The following table summarizes the results.

The results shows that l 1 ,B-methoxyl 7a-ethynyl-A estrene-l7B-ol-3-one possesses a considerable antiandrogenic activity at a dose of 1 mg.

Various modifications of the compositions and methods of the invention may be made without departing from the spirit or scope thereof and it is to be understood that the invention is to be limited only as defined in the appended claims.

We claim:

1. An antiandrogenic and antiestrogenic composition comprising an effective amount of a compound of the formula wherein R and X and alkyl of l to 4 carbon atoms, R is a saturated or unsaturated hydrocarbon of l to 6 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of l to 18 carbon atoms and Y and Y are selected from the group consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of l to 18 carbon atoms and a pharmaceutical carrier.

2. A method of inducing antiandrogenic and antiestrogenic activity in warm-blooded animals which comprises administering to warm-blooded animals an antiestrogenically and antiandrogenically effective amount of a compound of the formula wherein R and X are alkyl of l to 4 carbon atoms, R is a saturated or unsaturated hydrocarbon of l to 6 carbon atoms, R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of l to 18 carbon atoms and Y and Y are selected from the ground consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of l to 18 carbon atoms.

3. The method of claim 2 wherein the compound is l l B-methoxyl 7oz-ethynyl-A -estrenel 7B'ol-3-one.

4. The method of claim 2 wherein the compound is l l B-ethoxy-l 7a-ethynyl-A -estrenel 7 B-ol-3-one.

5. The method of claim 2 wherein the compound is l lB-methoxyl 3 B-ethyll 7a-ethynyl-A -gonene- 1 7 B- ol-3-one.

6. The method of claim 2 wherein the compound is l 1,8-methoxy-l 7a-ethynyll 7,8-butyryloxy-A -estrene- 3-one.

7. The method of claim 2 wherein the compound is l 1 B-methoxy-l 3 B-ethyll 7a-vinyl-A gonene-l 7 B-ol- 3-one.

8. The method of claim 2 wherein the compound is 3 l 7B-dibutyryloxyl l ,8-methoxyl 7a-ethynyl-A estradiene. 

1. AN ANTIANADROGENIC AND ANTIESTROGENIC COMPOSITION COMPRISING AN EFFECTIVE AMOUNT OF A COMPOUND OF THE FORMULA
 2. A method of inducing antiandrogenic and antiestrogenic activity in warm-blooded animals which comprises administering to warm-blooded animals an antiestrogenically and antiandrogenically effective amount of a compound of the formula
 3. The method of claim 2 wherein the compound is 11 Beta -methoxy-17 Alpha -ethynyl- Delta 4-estrene-17 Beta -ol-3-one.
 4. The method of claim 2 wherein the compound is 11 Beta -ethoxy-17 Alpha -ethynyl- Delta 4-estrene-17 Beta -ol-3-one.
 5. The method of claim 2 wherein the compound is 11 Beta -methoxy-13 Beta -ethyl-17 Alpha -ethynyl- Delta 4-gonene-17 Beta -ol-3-one.
 6. The method of claim 2 wherein the compound is 11 Beta -methoxy-17 Alpha -ethynyl-17 Beta -butyryloxy- Delta 4-estrene-3-one.
 7. The method of claim 2 wherein the compound is 11 Beta -methoxy-13 Beta -ethyl-17 Alpha -vinyl- Delta 4 gonene-17 Beta -ol-3-one.
 8. The method of claim 2 wherein the compound is 3,17 Beta -dibutyryloxy-11 Beta -methoxy-17 Alpha -ethynyl- Delta 3,5-estradiene. 